Born Enrique Jiménez Ramírez, in Marchena (Seville), he moved to Madrid at the age of 12. His father was the renowned guitarist Melchor de Marchena, who initiated him in the art of guitar accompaniment in flamenco singing.
At the early age of 15, he made his first public appearance at the famous Madrid tablao (Flamenco nightclub) Los Canasteros, owned by Manolo Caracol. He continued performing there for another five years, playing side by side with other great flamenco artists, including the maestro Mairena.
By the age of 18, he had been awarded two of the most important national flamenco awards: the National Award of the Chair of Flamencology of Jerez and the Castillete de Oro of La Unión (Murcia).
He joined a group of artists that performed regularly at Torres Bermejas, one of Madrid's most acclaimed tablaos, where he gave some unforgettable performances, being the guitar accompaniment to legendary flamenco singers such as Camarón de la Isla, La Perla de Cádiz, Pansequito, Turronero, Fosforito, etc. He has also performed with Paco de Lucía in worldwide concert tours.
Without abandoning his role as one of the most sought after guitar player to accompany cantaores, like his father, he wrote his own compositions and developed his skills as a concert guitarist, becoming one of the first ever flamenco artists to play solo guitar. He also toured as part of a short lived spectacular guitar trio together with Tomatito and Manzanita.
As a soloist, he has appeared in some of the world's greatest concert halls, namely the Queen Elizabeth Hallin London, Madrid's Teatro Real, the Liceo in Barcelona, Carnegie Hall in New York and at the United Nnations's General Assembly together with the Spanish National Symphony Orchestra, Montserrat Caballé, José Carreras and José Menese. He also performed in the annually held Madrid Jazz Festival.
Enrique de Melchor is one of the most solid professionals of flamenco guitar actually and he masters, as few others do, the difficult art of accompaniment.